Volume 6, Issue 3, September 2020, Page: 18-23
Possible Therapeutic Approach Against Covid-19 by Application of Magnetic Field
Md. Aminul Islam, Department of Physics, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh
Md. Ziaul Ahsan, Department of Physics, Bangladesh University of Engineering and Technology, Dhaka, Bangladesh; Department of Physics, Military Institute of Science and Technology, Dhaka, Bangladesh
Received: Jul. 27, 2020;       Accepted: Aug. 14, 2020;       Published: Oct. 17, 2020
DOI: 10.11648/j.ajn.20200603.11      View  67      Downloads  117
A new pandemic named as COVID-2019 (coronavirus disease 2019) has stunned the world. The reason behind this type of pandemic is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is similar to SARS CoV's epidemiology, genomics, and pathogens. This novel coronavirus (SARS-CoV-2) is causing the mainly pneumonia-associated respiratory syndrome, result in the death of human being which is increasing rapidly day by day. The current efforts of the scientist (both physical and biological) in the world is to invent specific antiviral drugs and physical therapeutic against COVID-19. Hence we have tried to discuss in this note how physical therapy may develope against COVID-19. To neutralize +ssRNA, M (membrane)-protein and spike protein-containing into SARS-CoV-2 magnetic field can play a vital role in the presence of nontoxic magnetic nanoparticles. To apply a magnetic field into the SARS-CoV-2, magnetic trap instrument called magnetic tweezers may be used where nontoxic magnetic nanoparticles act as a magnetic bead which alters the orientation of +ssRNA. At the same time, magnetic nanoparticles interacts with M-protein, result in fragmentation of spike protein. We expect that this therapy will be a more effective challenge to control the current pandemic and the possible re-emergence of the SARS-CoV-2 virus in the future.
COVID-19, Magnetic Nanoparticle, Magnetic Tweezers
To cite this article
Md. Aminul Islam, Md. Ziaul Ahsan, Possible Therapeutic Approach Against Covid-19 by Application of Magnetic Field, American Journal of Nanosciences. Vol. 6, No. 3, 2020, pp. 18-23. doi: 10.11648/j.ajn.20200603.11
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Fehr A. R. & Perlman S. (2015). Coronaviruses: An Overview of Their Replication and Pathogenesis. Methods in Molecular Biology, 1282, 1-23.
Anderson L. J., & Schneider E. (2012). Coronaviruses. Goldman’s Cecil Medicine, 2, 2102-2104.
Chen Y., Liu Q., &Guo D. (2020). Coronaviruses: genome structure, replication, and pathogenesis. Journal of Medical Virology (Accepted).
Sola I., Mateos-Gomez P. A., Almazan F., Zuñiga S., &Enjuanes L. (2011). RNA-RNA and RNA-protein interactions in coronavirus replication and transcription. RNA Biology, 8 (2), 237-248.
Hamidi M, Azadi A, Rafiei P, Ashrafi H. (2013) A pharmacokinetic overview of nanotechnology-based drug delivery systems: an ADME-oriented approach. Crit Rev Ther Drug Carrier Syst., 30 (5), 435-467.
Al-Halifa S., Gauthier L., Arpin D., Bourgault S., &Archambault D. (2019). Nanoparticle-Based Vaccines Against Respiratory Viruses. Frontiers in Immunology, 10, Article 22.
Dulin D., Arnold J. J., van Laar T., Oh H.-S., Lee C., Perkins A. L., Dekker N. H. (2017). Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers. Cell Reports, 21 (4), 1063-1076.
Gosse C, Croquette V (2002) Magnetic tweezers: micromanipulation and force measurement at the molecular level. Biophys J, 82, 3314-3329.
Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Zhang Y.-Z. (2020). A new coronavirus associated with human respiratory disease in China. Nature, DOI: 10.1038/s41586-020-2008-3.
de Wit E., van Doremalen N., Falzarano D., Munster VJ. (2016) SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol., 14 (8), 523-34.
Andrew M. Q. King, Michael J. Adams, Elliot J. Lefkowitz. (2011) Coronaviridae, Ch 24, 435-461.
Barcena M., Oostergetel G. T., Bartelink W., Faas F. G. A., Verkleij A., Rottier P. J. M., Bosch B. J. (2009). Cryo-electron tomography of mouse hepatitis virus: Insights into the structure of the coronavirion. Proceedings of the National Academy of Sciences, 106 (2), 582-587.
Neuman B. W., Adair B. D., Yoshioka C., Quispe J. D., Orca G., Kuhn P., … Buchmeier, M. J. (2006). Supramolecular Architecture of Severe Acute Respiratory Syndrome Coronavirus Revealed by Electron Cryomicroscopy. Journal of Virology, 80 (16), 7918-7928.
Molenkamp R., &Spaan W. J. M. (1997). Identification of a Specific Interaction between the Coronavirus Mouse Hepatitis Virus A59 Nucleocapsid Protein and Packaging Signal. Virology, 239 (1), 78-86.
Guo Y.-R., Cao Q.-D., Hong Z.-S., Tan Y.-Y., Chen S.-D., Jin H.-J. Yan Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status. Military Medical Research, 7 (1).
Kamitani W., Narayanan K., Huang C., Lokugamage K., Ikegami T., Ito N., Makino S. (2006). Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation. Proceedings of the National Academy of Sciences, 103 (34), 12885-12890.
Narayanan K., Huang C., Lokugamage K., Kamitani W., Ikegami T., Tseng C.-T. K., & Makino S. (2008). Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells. Journal of Virology, 82 (9), 4471-4479.
Züst R., Cervantes-Barragán L., Kuri T., Blakqori G., Weber F., Ludewig B., & Thiel V. (2007). Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines. PLoS Pathogens, 3 (8), e109.
Huang C., Lokugamage K. G., Rozovics J. M., Narayanan K., Semler B. L., & Makino S. (2010). Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Protein Suppresses Protein Translation in Mammalian Cells and in Cell-Free HeLa Cell Extracts but Not in Rabbit Reticulocyte Lysate. Journal of Virology, 85 (1), 638-643.
Kamitani W., Huang C., Narayanan K., Lokugamage K. G., & Makino S. (2009). A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein. Nature Structural & Molecular Biology, 16 (11), 1134-1140.
Tanaka T., Kamitani W., DeDiego M. L., Enjuanes L., & Matsuura Y. (2012). Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA. Journal of Virology, 86 (20), 11128-11137.
Thiel V. (2003). Mechanisms and enzymes involved in SARS coronavirus genome expression. Journal of General Virology, 84 (9), 2305-2315.
Lapps W., Hogue B. G., & Brian D. A. (1987). Sequence analysis of the bovine coronavirus nucleocapsid and matrix protein genes. Virology, 157 (1), 47-57.
Tang X., Wu C., Li X., Song Y., Yao X., Wu X., Lu, J. (2020). On the origin and continuing evolution of SARS-CoV-2. National Science Review doi.org/10.1093/nsr/nwaa036.
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020. https://doi.org/10.1038/s41586-020-2012-7.
Chen, L., Chen, C., Wang, P., & Song, T. (2017). Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields. Journal of Nanomaterials, 2017, 1-13.
Kilinc D., Dennis C. L., & Lee G. U. (2016). Bio-Nano-Magnetic Materials for Localized Mechanochemical Stimulation of Cell Growth and Death. Advanced Materials, 28 (27), 5672-5680.
Tom S. Tenforde Biomagnetic Effects Workshop, University of California, Berkeley, 1978. Magnetic field effect on biological systems, Plenum Press New York and London, Page 46.
Paul G. Higgs and Jean-François Joanny. (1990). Enhanced membrane rigidity in charged lamellar phases. J. Phys-Paris 51, 2307-2320.
Museveni S. J., Mohammad-Rezaei R., &Razmi H. (2018). Magnetic solid-phase extraction of malachite green using soluble eggshell membrane protein doped with magnetic graphene oxide nanocomposite. International Journal of Environmental Analytical Chemistry, 1-11.
Zablotskii V., Polyakova T., Lunov O., &Dejneka A. (2016). How a High-Gradient Magnetic Field Could Affect Cell Life. Scientific Reports, 6 (1), 37407.
Malka N. Halgamuge, Bertil R. R. Perssont, Leif G. Salford, PriyanMendis, and Jacob Eberhardt (2009). Comparison Between Two Models for Interactions Between Electric and Magnetic Fields and Proteins in Cell Membranes. Environmental engineering science. 26 (10), 1473-1480.
Bauréus Koch, C. L. M., Sommarin M., Persson B. R. R., Salford L. G., &Eberhardt J. L. (2003). Interaction between weak low-frequency magnetic fields and cell membranes. Bioelectromagnetics, 24 (6), 395-402.
Neuman, K. C., & Nagy, A. (2008). Single-molecule force spectroscopy: optical tweezers, magnetic tweezers, and atomic force microscopy. Nature Methods, 5 (6), 491-505.
De Vlaminck, I., & Dekker, C. (2012). Recent Advances in Magnetic Tweezers. Annual Review of Biophysics, 41 (1), 453-472.
Koster D. A., Croquette V., Dekker C., Shuman S., & Dekker N. H. (2005). Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. Nature, 434 (7033), 671-674.
Strick, T. R., Allemand J.-F., Bensimon D., Bensimon A., & Croquette V. (1996). The Elasticity of a Single Supercoiled DNA Molecule. Science, 271 (5257), 1835-1837.
Strick T. R., Allemand J.-F., Bensimon D., & Croquette V. (1998). The behavior of Supercoiled DNA. Biophysical Journal, 74 (4), 2016-2028.
D. Villan J. Lipfert D. A. Koster S. G. Lemay and N. H. Dekker Handbook of Single-Molecule Biophysics (Springer, New York, 2009), pp. 371-395.
Haber C., &Wirtz D. (2000). Magnetic tweezers for DNA micromanipulation. Review of Scientific Instruments, 71 (12), 4561.
Lansdorp B. M., Tabrizi S. J., Dittmore A., & Saleh O. A. (2013). A high-speed magnetic tweezer beyond 10,000 frames per second. Review of Scientific Instruments, 84 (4), 044301.
Brutzer H., Luzzietti N., Klaue D., & Seidel R. (2010). Energetics at the DNA Supercoiling Transition. Biophysical Journal, 98 (7), 1267-1276.
Lipfert J., Koster D. A., Vilfan I. D., Hage S., and Dekker N. H. (2009). Single-molecule Magnetic Tweezers Studies of Type IB Topoisomerases. Methods Mol. Biol. 582, 71.
Strick T. R., Croquette V., &Bensimon D. (2000). Single-molecule analysis of DNA uncoiling by a type II topoisomerase. Nature, 404 (6780), 901-904.
Revyakin A., Allemand J.-F., Croquette V., Ebright R., &Strick T. (2003). Single-Molecule DNA Nanomanipulation: Detection of Promoter-Unwinding Events by RNA Polymerase. RNA Polymerases and Associated Factors, Part C, 577-598.
Revyakin A., Liu C., Ebright R. H., &Strick T. R. (2006). Abortive Initiation and Productive Initiation by RNA Polymerase Involve DNA Scrunching. Science, 314 (5802), 1139-1143.
Lipfert J., Wiggin M., Kerssemakers J. W. J., Pedaci F., & Dekker N. H. (2011). Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids. Nature Communications, 2 (1).
Janssen X. J. A., Lipfert J., Jager T., Daudey R., Beekman J., & Dekker N. H. (2012). Electromagnetic Torque Tweezers: A Versatile Approach for Measurement of Single-Molecule Twist and Torque. Nano Letters, 12 (7), 3634-3639.
Celedon A., Nodelman I. M., Wildt B., Dewan R., Searson P., Wirtz D., … Sun S. X. (2009). Magnetic Tweezers Measurement of Single-Molecule Torque. Nano Letters, 9 (4), 1720-1725.
Lipfert J., Kerssemakers J. W. J., Jager T., & Dekker N. H. (2010). Magnetic torque tweezers: measuring torsional stiffness in DNA and RecA-DNA filaments. Nature Methods, 7 (12), 977-980.
Lavelle C. (2009). Forces and torques in the nucleus: chromatin under mechanical constraints this paper is one of a selection of papers published in this Special Issue, entitled 29th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer-review process. Biochemistry and Cell Biology, 87 (1), 307-322.
Chen L., Chen C., Wang P., & Song T. (2017). Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields. Journal of Nanomaterials, 2017, 1-13.
Fisher J. K., Cribb J., Desai K. V., Vicci L., Wilde B., Keller K., … Superfine R. (2006). Thin-foil magnetic force system for high-numerical-aperture microscopy. Review of Scientific Instruments, 77 (2), 023702.
Yan J., Skoko D., & Marko J. F. (2004). Near-field-magnetic-tweezer manipulation of single DNA molecules. Physical Review E, 70 (1).
Claudet C., &Bednar J. (2005). Magneto-optical tweezers built around an inverted microscope. Applied Optics, 44 (17), 3454.
Ahsan, M. Z., Khan, F. A., & Islam, M. A. (2019). Frequency and Temperature Dependent Dielectric and Magnetic Properties of Manganese Doped Cobalt Ferrite Nanoparticles. Journal of Electronic Materials. 48, 7721-7729.
Guo, T., Lin, M., Huang, J., Zhou, C., Tian, W., Yu, H., Feng, X. (2018). The Recent Advances of Magnetic Nanoparticles in Medicine. Journal of Nanomaterials, 2018, 1-8.
Islam, M. A., Ahsan, M. Z. (2020) Plausible Approach for Rapid Detection of SARS-CoV-2 Virus by Magnetic Nanoparticle Based Biosensors, American Journal of Nanosciences. 6 (2), 6-13.
Jiang, C., Lionberger, T. A., Wiener, D. M., &Meyhofer, E. (2016). Electromagnetic tweezers with independent force and torque control. Review of Scientific Instruments, 87 (8), 084304.
Corti, M., Lascialfari, A., Marinone, M., Masotti, A., Micotti, E., Orsini, F., Sangregorio, C. (2008). Magnetic and relaxometric properties of polyethyleneimine-coated superparamagnetic MRI contrast agents. Journal of Magnetism and Magnetic Materials, 320 (14), e316-e319.
Zhang, Y., Zhang, L., Song, X., Gu, X., Sun, H., Fu, C., &Meng, F. (2015). Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as a New MRI Contrast Agent. Journal of Nanomaterials, 2015, 1-6.
Kannoly, S., Shao, Y., & Wang, I.-N. (2012). Rethinking the Evolution of Single-Stranded RNA (ssRNA) Bacteriophages Based on Genomic Sequences and Characterizations of Two R-Plasmid-Dependent ssRNA Phages, C-1 and Hgal1. Journal of Bacteriology, 194 (18), 5073-5079.
Lysenko, V., Lozovski, V., Lokshyn, M., Gomeniuk, Y. V., Dorovskih, A., Rusinchuk, N.…Bolbukh, Y. (2018). Nanoparticles as antiviral agents against adenoviruses. Advances in Natural Sciences: Nanoscience and Nanotechnology, 9 (2), 025021.
Bu, Y., Hu, Q., Ke, R., Sui, Y., Xie, X., & Wang, S. (2018). Cell membrane camouflaged magnetic nanoparticles as a biomimetic drug discovery platform. Chem. Commun. 54, 13427.
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